Medicine Highlights
| Uses | 1. To treat pain and inflammation caused by conditions like osteoarthritis and rheumatoid arthritis. 2. To treat muscle pain and sprains. 3. To treat headache 4. To treat toothache and dental pain. 5. To treat fever and pain associated with infections 6. To relieve pain after surgery or injury. |
| Common Side Effects | 1. Stomach pain or discomfort (burning sensation, mild cramps) 2. Nausea or vomiting (feeling like you might throw up) 3. Diarrhea or constipation (changes in bowel habits) 4. Headache 5. Dizziness (feeling lightheaded) 6. Skin rash or itching |
| Additional Information | To keep you safe and healthy, use this medicine only with your doctor’s guidance. |
| Storage | 1- The medicine should be stored at room temperature 2- Keep away from sunlight and moisture 3- Keep away from the reach of children |
| How to Take This Medicine | This medication is taken orally |
Nimesulide Uses
Nimesulide 100 mg is an oral medicine that belongs to the class of NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) and is used to treat the following conditions:
- Pain and inflammation caused in conditions like osteoarthritis and rheumatoid arthritis
- Muscle pain
- Headache and toothache.
- Fever and pain associated with infections
- Pain after surgery or injury
Directions for use
- If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
- Take this medicine exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking this medicine without your doctor’s approval, even if you feel better.
Nimesulide side effects
More Common
- Stomach pain or discomfort (burning sensation, mild cramps)
- Nausea or vomiting (feeling like you might throw up)
- Diarrhea or constipation (changes in bowel habits)
- Headache
- Dizziness (feeling lightheaded)
- Skin rash or itching
Less Common
- Liver problems (yellowing of eyes/skin, dark urine, fatigue)
- Allergic reactions (swelling of face, lips, tongue, difficulty breathing)
- Severe stomach bleeding or ulcers (black/tarry stools, vomiting blood)
- Kidney problems (changes in urination, swelling in legs or feet)
How Nimesulide works
Nimesulide is an anti-inflammatory medicine. When your body is injured or sick, it produces certain chemicals called prostaglandins that cause pain, swelling, and fever. Nimesulide blocks these chemicals, so the pain and swelling go down and the fever reduces. It is usually gentler on the stomach than some other pain medicines, but it should still be taken with food or milk to avoid stomach upset.
Safety Measures and Warning
📌 Allergic individuals
If you are allergic to Nimesulide or similar painkillers (NSAIDs), taking it can cause rashes, swelling, or breathing problems, which can be dangerous. so, avoid it and tell your doctor immediately
📌 People with stomach problems
Those with stomach ulcers, bleeding, or severe gastritis should avoid it because Nimesulide can irritate the stomach lining and worsen bleeding.
📌 People with liver issues
Nimesulide is processed in the liver, so people with liver disease, jaundice, or previous liver problems are at risk of further damage to the organ. Hence, it should be avoided or used only under strict medical supervision.
📌 People with kidney problems
It can affect kidney function, so those with kidney disease should not use it.
📌 People with heart problems
People with heart disease or a history of stroke may have a higher risk of heart attack or stroke if they take Nimesulide, so they should avoid it or use it only under their doctor’s advice.
📌 Pregnant or breastfeeding women
It may harm the developing fetus, so it should only be used if a doctor specifically recommends it.
📌 Children under 12 years
Safety of nimesulide in young children is not well established, it is generally not recommended for them and should only be used if prescribed by a doctor.
Nimesulide Interaction with Other Medicines
Avoid taking Nimesulide with the following medicines, as it may increase or decrease the desired effect, or in worse cases and it could be fatal:
Nimesulide Interaction with Food Product
Avoid taking caffeinated food, alcohol and smoking with this medicine as they can alter drug’s action; also, they may cause severe drowsiness and sedation as they act on the brain directly.
Storage
- Store the medicine at room temperature
- Keep away from sunlight and moisture
- Keep out of reach of children
Nimesulide Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name
N-(4-nitro-2-phenoxyphenyl)methane sulfonamide
Intake routine/cycle
📌 Daily dose
Take Nimesulide exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
📌 Missed Dose
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
📌 Overdose
Don’t take more than 200 mg of nimesulide per day, as it may cause severe stomach pain, vomiting, dizziness, drowsiness, difficulty breathing, liver problems, or even fainting. Seek medical support immediately if you experience any such overdose symptoms.
Nimesulide Summary
Nimesulide is a pain-relieving and anti-inflammatory medicine that belongs to the NSAID group. It is used to reduce pain, swelling, and fever, and is commonly prescribed for headaches, toothaches, muscle pain, joint pain, pain after injuries or surgery, and fever caused by infections. Nimesulide works by blocking chemicals in the body called prostaglandins that cause pain and inflammation, helping you feel more comfortable. Common side effects include stomach pain, nausea, diarrhea or constipation, headache, dizziness, and mild skin rash, while rare but serious effects may involve liver problems, severe stomach bleeding, kidney issues, or serious allergic reactions. Nimesulide should not be taken by people with allergies to it, stomach ulcers, liver or kidney problems, heart disease, pregnant or breastfeeding women, or children under 12 years, and it is best taken with food or milk to avoid stomach irritation. Alcohol should be avoided, and any unusual symptoms should be reported to a doctor immediately.
FAQ’s
1. What are the uses of Nimesulide?
➡️ Nimesulide is used to relieve pain, reduce swelling, and lower fever. It helps with headaches, toothaches, muscle pain, joint pain, pain after injuries or surgery, and fever caused by infections.
2. What are the common side effects of Nimesulide?
➡️ Common side effects include stomach pain, nausea, diarrhea or constipation, headache, dizziness, and mild skin rash.
3. Can I use Nimesulide for headache?
➡️ Yes, Nimesulide is often used to relieve headaches, including tension headaches or pain from mild migraines. It works by reducing the chemicals in your body that cause pain and inflammation, helping you feel better.
4. What is the drug class of Nimesulide?
➡️ Nimesulide is a painkiller and anti-inflammatory medicine. It belongs to the NSAID group, which works by reducing the chemicals in your body that cause pain, swelling, and fever.
Reference
- Nimesulide [Internet]. go.drugbank.com. Available from
- PubChem. Nimesulide [Internet]. pubchem.ncbi.nlm.nih.gov. Available from
- Truemeds [Internet]. Truemeds.in. 2019 [cited 2025 Sep 2]. Available from
- 1mg.com. Nimesulide: View Uses, Side Effects and Medicines | 1mg [Internet]. 1mg. 2024 [cited 2025 Sep 2]. Available from
